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3rd International Conference on Molecular Medicine and Diagnostics, will be organized around the theme “Exploring the modern Innovations in the field of Molecular Medicine and Diagnostics”
Molecular Medicine 2018 is comprised of keynote and speakers sessions on latest cutting edge research designed to offer comprehensive global discussions that address current issues in Molecular Medicine 2018
Submit your abstract to any of the mentioned tracks.
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Cancer immunology is a branch of immunology that involves the interaction of cancer cells and immune system in which imuune system respond to cancer cells in two different ways. It is a growing field of research that aims to discover innovative cancer immunotherapies to treat and retard progression of the disease. The immune response, includes the identification of cancer-specific antigens and it opened a new possibilities for the development of effective immunotherapies related to cancer .One of the hottest ideas in science is that you can stimulate the immune system to fight cancer. There has been surge in such a way that the molecular pathways of this cancer-related inflammation are now being unravelled, resulting in the identification of new target molecules that could lead to improved diagnosis and treatment.
The Cancer Immunotherapy Market will increase to nearly $9 Billion across the World’s major Pharmaceutical Markets in 2022. The immunotherapy market will experience considerable growth through 2022, increasing from $1.1 billion in 2012 to nearly $9 billion in 2022 (corresponding to 23.8 percent annual growth) in the United States, France, Germany, Italy, Spain, United Kingdom and Japan.
- Track 1-1Cancer & Tumor Immunology
- Track 1-2Cancer Immunology
- Track 1-3Immunology & Immunotherapy
- Track 1-4Inflammation and Cancer
- Track 1-5Tumor Microenvironment
Gene therapy is the therapeutic delivery of nucleic acid polymers into a patient's cells as a drug to treat disease. The polymers are either expressed as proteins, interfere with protein expression, or possibly correct genetic mutations. Gene therapy utilizes the delivery of DNA into cells, which can be accomplished by several methods. The two major classes of methods are those that use recombinant viruses (sometimes called biological nanoparticles or viral vectors) and those that use naked DNA or DNA complexes (non-viral methods).
The most common form uses DNA that encodes a functional, therapeutic gene to replace a mutated gene. The polymer molecule is packaged within a "vector", which carries the molecule inside cells. Gene therapy was conceptualized in 1972, by authors who urged caution before commencing human gene therapy studies. The first gene therapy experiment approved by the US Food and Drug Administration (FDA) occurred in 1990, when Ashanti DeSilva was treated for ADA-SCID. By January 2014, some 2,000 clinical trials had been conducted or approved.
Tumor suppressor gene is a gene that protects a cell from one step on the path to cancer. When this gene mutates to cause a loss or reduction in its function, the cell can progress to cancer, usually in combination with other genetic changes. Systems medicine is an interdisciplinary field of study that looks at the systems of the human body as part of an integrated whole, incorporating biochemical, physiological, and environment interactions. Systems medicine draws on systems science and systems biology, and considers complex interactions within the human body in light of a patient's genomics, behavior and environment.
- Track 2-1Gene Therapy
- Track 2-2Gene Editing Technology
- Track 2-3Advanced Gene Therapeutics
- Track 2-4Manufacturing of Gene Therapeutics: Methods, Processing and Regulation
- Track 2-5Tumor suppressor gene Therapy
Current Research in Molecular Medicine is an International Peer Reviewed Open Access journal presenting original research contributions and scientific advances in the field of Molecular Medicine. Covering broad research areas, CRMM aims to promote information in the area of Molecular Medicine and related sciences and enhance the exchange of scientific literature among peers. It also serves as a platform to promote meetings and news related to advances in Molecular Medicine.
Current Research in Molecular Medicine welcomes research articles, review articles, case reports, editorials, letters to the editor and innovations related to all aspects of Molecular Medicine and related sciences.
- Track 3-1Cancer molecular diagnostics
- Track 3-2Implications of molecular medicine in the treatment of HIV
- Track 3-3Molecular medical microbiology
- Track 3-4Clinical molecular biology
- Track 3-5 Molecular Diagnostics companies and Marketing
- Track 3-6Molecular Diagnostics Business Oppourtunities
Cellular medicine incorporates a wide range of biological processes from structure and function of biomolecules to cell physiology to understand the abnormal biological function at the cellular level. Cell therapy is used for the treatment of diseases like cancer by injecting living whole cell or maturation of a specific cell population in a patient. Cell therapy is expanding its repertoire of cell types for administration. Cell therapy treatment strategies include isolation and transfer of specific stem cell populations, administration of effector cells, induction of mature cells to become pluripotent cells, and reprogramming of mature cells. Administration of large numbers of effector cells has benefited cancer patients, transplant patients with unresolved infections, and patients with chemically destroyed stem cells in the eye.
- Track 4-1Cell therapy
- Track 4-2Bioinformatics
- Track 4-3Molecular diagnostics
Cell therapy involves a therapy in which cellular material is injected into a living cells. For example, T cells capable of fighting cancer cells via cell-mediated immunity may be injected in the course of immunotherapy. Molecular Therapy is the cellular modifications at the molecular level. Take the chemotherapy in oncology for example, it aims to kill the cell by delivering toxic agents to the cell, while Molecular therapies could aim to terminate the cellular division without necessarily killing the cell, such as aiming to reach senescence whose therapeutic procedure, levels of toxic agents, and tools for delivering the toxicity could all be very different from simply killing the cell. Cardiovascular Cell Therapy Research Network (CCTRN) to improve the outcomes of patients with diseases of the heart and cardiovascular system as it involves network of physicians, scientists, and support staff dedicated to studying stem cell therapy for treating heart disease. The CCTRN is funded by the National Institutes of Health (NIH) and includes expert researchers with experience in cardiovascular care at five stem cell centers in the United States. CCTRN conducts clinical trials that focus on providing cell therapy to patients with cardiovascular diseases that will potentially lead to more effective treatments and it helps in sharing knowledge quickly with the healthcare community. Genetic Screening is an analysis of DNA samples to detect the presence of a gene or genes associated with an inherited disorder. RNA Therapeutics Market is expected to reach $1.2 Billion, Globally, by 2020 - Allied Market Research.
- Track 5-1Cardiovascular Cell Therapy Research
- Track 5-2Cell & Gene Therapy Bioprocessing & Commercialization
- Track 5-3Cell & Gene Therapy Insights
- Track 5-4Cell Line Development
- Track 5-5Tissue Science & Regenerative Medicine
- Track 5-6Molecular Basis of Epigenetics
Pathology is a significant component of the medical sciences to understand the nature of the disease and a major field in diagnosis and modern medicine. It incorporates a wide range of medical practices and bioscience research to diagnose disease mostly by analysing cells, tissues and body fluids. Molecular medicine is an emerging area that aims to understand the molecular determinants of disease and health for the prevention, diagnosis and treatment using physical, chemical, biological and medical techniques. It aims to understand how health is maintained and the origins and mechanisms of human diseases. The molecular medicine perspective emphasizes cellular and molecular phenomena and interventions rather than the previous conceptual and observational focus on patients and their organs.
- Track 6-1Clinical Pathology
- Track 6-2Pediatric Pathology and Molecular Medicine
- Track 6-3Cellular and Molecular Medicine
Cancer stem cells (CSCs) have been reported to play critical roles in the tumor initiation, propagation, and regeneration of cancer. Nano-size vehicles are employed to deliver drugs to target the CSCs for cancer therapy. Polymeric nanoparticles have been considered as the most efficient vehicles for drug delivery due to their excellent pharmacokinetic properties. The CSCs specific antibodies or ligands can be conjugated onto the surface of the nanoparticles to successfully target and eliminate CSCs.
In this review, we emphasize on the techniques of polymeric nanoparticles design for loading drug, and their potential application for CSCs targeting in cancer therapy.
- Track 7-1Stem cell migration
- Track 7-2Cell Migration and Durotaxis
- Track 7-3Stem cell differentiation
Stem cell therapy has recently progressed from the preclinical to the early clinical trial for a variety of disease conditions. Stem cell is an undifferentiated cell which is capable of transforming into more cells of same type or multiple other types. They are found in multicellular organisms. They can differentiate into cells of blood, skin, heart, muscles, brain etc. In adult human being, they replenish the dead cells of various organs. Stem cells are being used for treatment of various diseases like diabetes, arthritis, few cancers, bone marrow failure etc. Stem cell therapy is potentially applicable to all subspecialties of medicine, but both articles stress that caution is required in interpreting the current role of these technologies in medical practice. Recent researches are carried on the use of stem cells for cardiac repair and bone disorders.
- Track 8-1 Stem Cell Research and Treatment
- Track 8-2Stem cells translational medicine
- Track 8-3Current Protocols in Stem Cell Biology
Stem Cell Biology and Research includes all aspects of stem cells and regenerative medicine, genetics, cell biology, developmental biology and molecular biology epigenetics. Stem Cell Biology and Research welcome original research articles, reviews, and hypothesis emphasizing the characterization of stem cells, signalling pathways, biochemistry and stem cell micro-environment. Stem cells are capable of dividing to produce more of themselves and to produce other specialised cell types that an organism needs to develop and live. In the adult, they can replenish cells that have died due to disease or injury. The process by which a cell changes from one type to another is called ‘differentiation’. Cells that have acquired their final function are said to be ‘differentiated’. Initially, stem cells are said to be ‘undifferentiated’. In a mammalian embryo a few days old, a small group of cells called the ‘inner cell mass’ is formed. These master stem cells give rise to the main cell types of the body. Embryonic stem (ES) cells are produced from the inner cell mass in the laboratory. Throughout development, different stem cells are formed that produce the specialised tissues and organs. The blood and skin contain stem cells that are constantly replenishing cells lost or dying. In other tissues, stem cells are much rarer. We are trying to identify and purify stem cells in various tissues.
- Track 9-1Cell Biology
- Track 9-2Insights in Stem Cells
- Track 9-3Genetics & Stem Cell Biology
- Track 9-4Stem Cell Research and Therapy
One of the original hypotheses of organismal longevity posits that aging is the natural result of entropy on the cells, tissues, and organs of the animal—a slow, inexorable slide into nonfunctionality caused by stochastic degradation of its parts. We now have evidence that aging is instead at least in part genetically regulated. Many mutations have been discovered to extend lifespan in organisms of all complexities, from yeast to mammals. Oxidative stress and mitochondrial damage have been implicated in the pathogenesis of several neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis. Oxidative stress is characterized by the overproduction of reactive oxygen species, which can induce mitochondrial DNA mutations, damage the mitochondrial respiratory chain, alter membrane permeability, and influence Ca2+ homeostasis and mitochondrial defense systems. Free radicals reactive oxygen species and reactive nitrogen species are generated by our body by various endogenous systems, exposure to different physiochemical conditions or pathological states. A balance between free radicals and antioxidants is required for proper physiological function. If free radicals overwhelm the body's ability to regulate them, a condition known as oxidative stress ensues. Free radicals thus adversely change the lipids, proteins, and DNA and trigger a number of human diseases.
- Track 10-1Age related disorders
- Track 10-2Oxidative stress and cellular degeneration
- Track 10-3Free radicals and antioxidants
- Track 10-4Cellular aging and influence of diet
Molecular medicine (the applications of DNA knowledge to medical practice) has moved into the genomics era with the promise that personalized medical care will now be greatly enhanced, including the options for more effective prevention and the development of new therapies targeted to molecular defects. At the same time, the traditional health professional-patient interaction is being challenged by the growth of Internet-based direct-to-consumer DNA testing and counseling. The increasing internationalization of genomic research has led to the development of more effective approaches to studying complex multifactorial genetic disorders, while at the same time highlighting new challenges in ethical, legal and social issues. In this complex environment, students and a wide range of health professionals need to keep abreast of new developments (often driven by the public, media or the Internet) while not necessarily having the opportunity or time to understand the basics.
Personalized healthcare refers specifically to the use of genetics and genomics. An example of that medicine includes the uses of specific tumor markers to guide therapy for breast cancer. We view personalized healthcare as a broader platform that includes genetics and genomics but also includes any other biologic information that helps predict risk for disease or how a patient will respond to treatments. Most genetic disorders are quite rare and affect one person in every several thousands or millions. Molecular and Cellular Therapies is the cellular modifications at the molecular level. Take the chemotherapy in oncology for example, it aims to kill the cell by delivering toxic agents to the cell, while Molecular therapies could aim to terminate the cellular division without necessarily killing the cell, such as aiming to reach senescence whose therapeutic procedure, levels of toxic agents, and tools for delivering the toxicity could all be very different from simply killing the cell. Physicians specializing in internal medicine are called internists or physicians (without a modifier) in Commonwealth nations.
- Track 11-1Pharmacoproteomics in Personalized Medicine
- Track 11-2Plant Genomics
- Track 11-3Preventive Medicines
- Track 11-4Regulatory Of Personalized Medicine
- Track 11-5Treatment Of Genetic Disorders
- Track 11-6Treatment Of Immune Disorders
- Track 11-7Treatment Of Infectious Diseases
- Track 11-8Treatment Of Neurological & Psychiatric Disorders
- Track 11-9Cell & Gene Therapy Insights
Molecular diagnostics is a collection of techniques used to analyses biological markers in the genome and proteome, in which individual's genetic code and how their cells express their genes as proteins—by using medical checkup and molecular biology. The technique is applied to diagnose and monitor disease, check risk, and decide which therapies will work best for individual patient. By analyzing the disease of the patient and their molecular diagnostics, offers the prospect of personalized medicines.
These tests are useful in a range of medical experts including infectious disease, oncology coagulation, and pharmacogenomics—the genetic prediction of which drugs will work best. They overlap with clinical chemistry.
- Track 12-1 Developements of invasively-obtained samples for parental testing
- Track 12-2Advances in Prenatal Molecular Diagnostics
- Track 12-3Advanced Diagnostics for Infectious Disease
- Track 12-4Commercial Biologics Development
- Track 12-5Immunogenicity Testing
- Track 12-6Molecular Testing
- Track 12-7Molecular Biology
- Track 12-8Molecular Diagnostics
Molecular Biomarker is a measurable indicator of the severity or presence of some disease state. More generally a biomarker is anything that can be used as an indicator of a particular disease state or some other physiological state of an organism. DNA marker is the term used to refer to a specific DNA variation between individuals that has been found to be associated with a certain characteristic. These different DNA or genetic variants are known as alleles. A genetic marker is used to identify individuals or species and to associate inherited desease. It can be described as a variation (which may arise due to mutation or alteration in the genomic loci) that can be observed. A genetic marker is used to identifie not only traits but also to characterize germ plasm.
A DNA microarray are also commonly known as DNA chip or biochip are used to identify and detect bacterial pathogens and are not limited to gene expression. They are attached to a solid surface of microscopic DNA spots.
- Track 13-1Biomarkers & Personalised Medicine
- Track 13-2Biomarkers in drug development
- Track 13-3Biomarkers and system Biology
- Track 13-4Predictive Biomarkers
- Track 13-5Biomarker Diagnostic Market
- Track 13-6Genetic Biomarkers
- Track 13-7Cancer Biomarkers
- Track 13-8Biomarkers & Molecular Diagnostics
- Track 13-9Biomarkers Technologies
- Track 13-10Stem Cell Biomarkers
- Track 13-11Molecular Imaging and Dynamics
Molecular evolution is a change at the level of DNA sequence and it includes the study in the changes in genomic structure of cellular molecules. The field of molecular evolution uses principles of evolutionary biology and population genetics to explain patterns in these changes. Major topics in molecular evolution concern the rates and impacts of single nucleotide changes, neutral evolution vs. natural selection in which origins of new genes, the genetic nature of complex traits, the genetic basis of speciation, evolution of development, and ways that evolutionary forces influence genomic and phenotypic changes. DNA sequencing is the process of determining the sequence of As, Ts,Cs,Gs (nucleotides bases) in a DNA molecule. It includes any method or technology that is used to determine the order of the four bases—adenine, guanine, cytosine, and thymine—in a strand of DNA. The advent of rapid DNA sequencing methods has greatly a ccelerated biological and medical research and discovery. Metagenomics is the study of genetic material recovered directly from environmental samples. The broad field may also be referred to as environmental genomics, ecogenomics or community genomics.
- Track 14-1Genome Biology & Evolution
- Track 14-2Molecular Oncology
- Track 14-3Protein Evolution
- Track 14-4Plant Molecular Evolution
- Track 14-5Genome Architecture