Fatemeh Bandarian
Tehran University of Medical Sciences, Iran
Title: Association between the APOA1 rs201148448 and metabolic syndrome in Iranian population
Biography
Biography: Fatemeh Bandarian
Abstract
Metabolic Syndrome (MetS) increases the risk for cardiovascular disease and diabetes. This study aim was to investigate the association between APOA1 polymorphisms and MetS in an Iranian population. Thirty-seven patients with MetS and 94 healthy controls were selected randomly from the population of Tehran Lipid and Glucose Study. Variant was identified by direct sequencing. The mean age of participants in MetS and control groups was 44.76±14.25 and 38.74±15.37, respectively. Frequency of mutant allele in MetS group was 1.35% while its frequency in control group was 13.8%. There was a significant association between rs201148448 and MetS. Also, there was a significant association between rs201148448 and serum triglyceride and HDL concentration as well as BMI and waist circumference (p=0.001). APOA1 variants rs201148448 contribute in MetS phenotype and protect against it in Iranian population. In relation to MetS, variants in other variants of APOA1 gene should be studied in future.