Janak Kishore
Sanjay Gandhi Post-Graduate Institute of Medical Sciences, India
Title: Human parvovirus B19 infections have emerged but given a back seat: A pioneer work from India indicates high disease burden
Biography
Biography: Janak Kishore
Abstract
Parvovirus B19 (B19), (discovered 1975) listed as newly emerging virus (1981-1987) but could not gain importance due to asymptomatic/self-limiting infections, myriads of clinical afflictions not known to many clinicians, limited diagnostic facilities, unknown disease burden and sinister complications. Hence in-house diagnostic methods of DNA extraction from serum, PCR, nested-PCR, IgM and IgG ELISA were standardised. Seroprevalence of B19 was found to be 39.9% among 1000 blood donors i.e. 60% of Indian population (1.2 billion) at risk of B19. We published fatal cases of B19 induced pure red cell aplasia, thrombocytopenia with hepatitis and hemophagocytic syndrome. B19 infections were unveiled by us in 27.5% arthropathy (n=69), 19.8% recurrent aborters (n=116), 60% high-risk pregnant women (n=60), 17.1% paediatric haematological malignancies (n=35) and 41% beta-thalassemia major (n=90). Novel clinical associations like amegakaryocytic thrombocytopenia ,myositis as a complication of erythema infectiosum and recently non-occlusive ischemic gangrene of stomach and bowel were reported. Our limited work denotes high/alarming situation of B19 infections, hence B19 be looked/recognised and prevented by a licensed B19 vaccine.
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