Liubov A Tashireva
Tomsk Cancer Research Institute, Russian Federation
Title: Microenvironment of morphologic structures of invasive carcinoma NST
Biography
Biography: Liubov A Tashireva
Abstract
Invasive carcinoma of non-specific type (IC NST) is characterized by different morphological structures presence. These structure is divided into two subtypes. The first group includes tubular, trabecular structure and discrete tumor cells and is characterized association of tumor cells not only with other tumor cells, but with the stroma. The second group, which includes solid and alveolar structure characterized connections between tumor cells without any connection with the stroma excepting external layer of cells. Significance of morphological intratumoral heterogeneity of IC NST described for tumor progression dependent on the menstrual status of patients. Furthermore, our research team demonstrated that the presence of alveolar structures increases the risk of nodal metastasis of IC NST. However, until now the role of the microenvironment of various structures in tumor progression is unknown. Gene expression analyze shows heterogeneity of microenvironment of morphological structures of IC NST. The microenvironment of alveolar structures presented Th2-type immune response. Since the properties of the tumor microenvironment is closely interact with tumor progression. It can be concluded that the development of Th2 immune response in microenvironment of alveolar structures contributes to the manifestation its invasive properties.