Biography
Biography: Mohamed El-Tanani
Abstract
Ran is a Ras-related GTPase that is critical for mitosis, apoptosis and nucleo-cytoplasmic transport. Ran is overexpressed in cancer cell lines and tumour tissues at both the mRNA and protein levels compared with their normal counterpart. It has been shown that cancer cells are more susceptible to Ran silencing than normal cells. mRNA and protein levels of Ran are shown to be a prognostic marker for poor prognosis in both breast and lung cancers. Ran prognostic significance is dramatically enhanced in cancers with increased c-Met, c-myc or OPN expression or with oncogenic mutation of KRas or PI3KCA, that correlate with activation of the PI3K/Akt/mTORC1 and Ras/MEK/ERK pathways. These results suggest that overexpression of Ran in clinical specimens is significantly associated with poor patient outcome in both breast and lung cancers.