Jeng Long Hsieh
Chung Hwa University of Medical Technology, Taiwan
Title: Targeting estrogen receptor has a therapeutic implication for the treatment of de Quervain’s disease
Biography
Biography: Jeng Long Hsieh
Abstract
De Quervain’s disease, or stenosing tenosynovitis of the first dorsal compartment of the wrist, is a common ailment. How estrogen is involved in this disease is not clear. We previously showed that inflammation was involved in the pathogenesis of de Quervain’s disease. In this study, the expression of estrogen receptor (ER)-ï¢ is further examined to delineate the possible roles of estrogen in this disease. Postoperative retinaculum samples were collected from 16 patients with de Quervain’s disease. The specimens were histologically graded by collagen structure. They were immunohistochemically evaluated by quantifying the expression of ER-ï¢, interleukin (IL)-1ï¢, IL-6, cyclooxygenase (COX)-2, vascular endothelial growth factor (VEGF), and Von Willebrand’s factor (vWF). De Quervain’s disease occurs primarily in women. The female:male ratio in our study was 7:1. ER-ï¢ was detected in the retinaculum and its expression increased with the grade of the disease and the age of the patient. Moreover, disease severity was related to the inflammatory cytokines IL-1ï¢ and IL-6, the inflammatory enzyme COX-2, and the angiogenic factors VEGF and vWF in the tenosynovial tissue. The severity of de Quervain’s disease is associated with increased ER-ï¢ expression, tissue inflammation, and angiogenesis. ER-ï¢ might be a useful target for treating de Quervain’s disease.