Day 1 :
The Wistar Institute, USA
Keynote: Improving the outcome of T-cell immunotherapy of cancers by pre-conditioning T cell metabolism towards fatty acid catabolism
Time : 09:30-10:15
Recent years have shown tremendous progress in active immunotherapy of cancers through tumor antigen (TA)-specific vaccines, adoptive T cell transfer or check point inhibitors. Nevertheless complete cures remain rare. TA-specific CD8+ T cells rapidly become exhausted once they enter solid tumors. This exhaustion, causing loss of tumor infiltrating CD8+ T cells during tumor progression, is in part cause by metabolic constrains, such as hypoxia and hypoglycemia, within the tumor microenvironment (TME). Lack of glucose forces T cells to switch from glycolysis for energy and biomass production to fatty acid catabolism. Most T cells are apparently unable to adjust their metabolism within the TME and as a consequence loose functions and eventually die. Pre-conditioning T cells during their initial activation in lymphatic tissues or their expansion in vitro towards fatty acid beta oxidation (FAO) preserves their functions and allows them to more effectively reduce tumor burden. CD8+ T cell metabolism can be modified by different types of manipulations such as knockdown of HIF-1a or other key factors of the glycolysis pathway to reduce the cells’ reliance on glucose. FAO can be enhanced directly by strengthening signaling through PPAR-a, the master regulator of lipid metabolism.
University of Oslo, Norway
Keynote: Impact of vitamin K2 on the prevention and treatment of various metabolic end endocrine diseases,discussing the implications of vitamin K2 in hormonal (G-protein) signaling, as well as integration with the effects of vitamins A and D3
Time : 10:15-11:00
Dr. Jan O. Gordeladze, PhD (born 25th of April, 1950), holds a triple professor competence (medical biochemistry, physiology, and pharmacology), and is presently working as a professor at the Department of Biochemistry, Institute of Basic Medical Science, University of Oslo, Norway. He has previously been employed as the medical director of MSD, Norway, serving two years as a Fulbright scholar at the NIH, Bethesda, Maryland, USA, and from 2006-2009 also being employed as associate professor at the University of Montpellier, France. He is a member of the Norwegian Stem Cell Center, and his research has over the past 7-10 years been devoted to differentiation of osteochondral cells from stem cells focusing on the impact of transcription factors and microRNA species constituting regulatory loop interactions with functional target genes. He has published more than 120 scientific articles, reviews/book chapters and presented more than 250 abstracts/posters/talks at conferences world wide. Dr. Gordeladze has served as a Fulbright Scholar at the National Institute of Health, Bethesda, Washington DC during the years 1990-91.
To be updated
Westhill University, Mexico
Keynote: RegenerAge System: Therapeutic effects of combinatorial biologics(mRNA and Allogenic MSCs) with a spinal cord stimulation system on a patient with spinal cord section towards fatty acid catabolism
Time : 14:00-14:40